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| Haveric,Sanin; Hadzic,Maida; Haveric,Anja; Mijanovic,Mirjana; Hadziselimovic,Rifat; Galic,Borivoj. |
| ABSTRACT Genotoxic effects of inorganic molecule dipotassium-trioxohydroxytetrafluorotriborate, K2(B3O3F4OH), a promising new therapeutic for the epidermal changes treatment, have been evaluated. In vitro analysis included evaluation of genotoxic and cytotoxic potential of K2(B3O3F4OH) in concentrations of 0.01, 0.02, 0.05 and 0.06 mg/mL applying cytokinesis-block micronucleus cytome assay in human lymphocyte culture. With the increase of concentration the frequency of micronuclei elevated but the differences were not significant. Also, there were no significant differences among the frequencies of nuclear buds and nucleoplasmic bridges between controls and treated cultures. Nuclear division index and nuclear division cytotoxycity index values did not... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Genotoxicity; Micronuclei; Halogenated boroxine; Human lymphocyte culture; BALB/c mice. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132016000100348 |
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